Meatloaf Grilled Cheese


Combine two classic comfort foods into one deliciously satisfying dish with our Meatloaf Grilled Cheese recipe. Imagine biting into a warm, gooey grilled cheese sandwich filled with savory meatloaf, melted cheese, and a hint of tangy sauce. This ultimate comfort food mashup is perfect for cozy nights in, lazy weekend lunches, or anytime you’re craving a hearty and indulgent meal. In this article, we’ll share the secrets to making this mouthwatering Meatloaf Grilled Cheese and why it’s sure to become a new favorite in your recipe collection.


For the Meatloaf:

  • 1 pound ground beef
  • 1 cup breadcrumbs
  • 1/2 cup milk
  • 1/2 cup onion, finely chopped
  • 1/2 cup bell pepper, finely chopped
  • 2 cloves garlic, minced
  • 1/4 cup ketchup
  • 1 tablespoon Worcestershire sauce
  • 1 teaspoon dried oregano
  • Salt and black pepper to taste

For the Grilled Cheese:

  • Sliced bread
  • Butter, softened
  • Sliced cheddar cheese
  • Sliced mozzarella cheese


For the Meatloaf:

  1. Preheat the oven to 375F 190C.
  2. In a bowl, combine ground beef, breadcrumbs, milk, chopped onion, chopped bell pepper, minced garlic, ketchup, Worcestershire sauce, dried oregano, salt, and black pepper.

Mix until well combined.

  1. Transfer the mixture to a greased loaf pan, shaping it into a loaf.
  2. Bake in the preheated oven for 45-50 minutes or until the meatloaf is cooked through.

For the Grilled Cheese:

  1. Once the meatloaf is cooked, let it cool slightly, then slice it into 1/2-inch thick slices.
  2. Butter one side of each slice of bread.
  3. On the non-buttered side, place a slice of cheddar cheese, a slice of meatloaf, and a slice of mozzarella cheese.
  4. Top it with another slice of bread, buttered side facing out.
  5. Heat a skillet over medium heat and cook the sandwich on both sides until the bread is golden brown, and the cheese is melted.

Serving Tips:

  1. Cut into Halves or Triangles: After grilling the Meatloaf Grilled Cheese sandwiches, slice them diagonally into halves or triangles for a visually appealing presentation. This also makes them easier to handle and enjoy.
  2. Garnish with Fresh Herbs: Before serving, garnish the sandwiches with a sprinkle of fresh herbs such as chopped parsley or chives. This adds a pop of color and freshness to the dish.
  3. Serve with Dipping Sauce: Accompany the Meatloaf Grilled Cheese sandwiches with a side of your favorite dipping sauce, such as ketchup, barbecue sauce, or ranch dressing. This adds an extra layer of flavor and enhances the overall dining experience.
  4. Pair with Soup or Salad: For a complete meal, serve the sandwiches alongside a bowl of warm soup or a crisp green salad. The contrast in textures and flavors creates a well-balanced and satisfying dining experience.
  5. Enjoy Immediately: Meatloaf Grilled Cheese sandwiches are best enjoyed hot and fresh off the grill. Serve them immediately to ensure that the cheese is gooey and melted, and the bread is crispy and golden brown.

Storage Tips:

  1. Refrigeration: If you have leftovers, store the cooled Meatloaf Grilled Cheese sandwiches in an airtight container or wrap them tightly in aluminum foil. Place them in the refrigerator and consume within 2-3 days.
  2. Reheating: To reheat refrigerated sandwiches, preheat the oven to 350°F (175°C) and place the sandwiches on a baking sheet. Bake for 10-15 minutes or until heated through. Alternatively, reheat them in a skillet over medium heat until warmed to your liking.
  3. Freezing: While it’s not recommended to freeze fully assembled Meatloaf Grilled Cheese sandwiches due to changes in texture, you can freeze the individual components separately. Freeze slices of meatloaf and shredded cheese in airtight containers for up to 2-3 months. Thaw them in the refrigerator before assembling and grilling fresh sandwiches.
  4. Assemble and Grill Fresh: For the best taste and texture, it’s preferable to assemble and grill the Meatloaf Grilled Cheese sandwiches fresh rather than preparing them in advance and reheating later. This ensures that the bread remains crispy and the cheese melts perfectly.
  5. Quality Check: Before consuming reheated sandwiches, ensure that they are heated thoroughly to an internal temperature of 165°F (74°C) to ensure food safety. Discard any sandwiches that show signs of spoilage, such as off odors or unusual texture.


  1. Can I use any type of meatloaf for this recipe? Yes, you can use any type of meatloaf for the Meatloaf Grilled Cheese recipe. Whether it’s homemade meatloaf, store-bought meatloaf, or even vegetarian meatloaf, feel free to use your favorite variety to suit your taste preferences.
  2. What kind of cheese works best for this grilled cheese sandwich? While cheddar cheese is a classic choice for grilled cheese sandwiches, you can use any type of cheese that melts well. Some popular options include American cheese, Swiss cheese, provolone cheese, or mozzarella cheese. Feel free to mix and match cheeses for a unique flavor profile.
  3. Can I make this recipe gluten-free? Yes, you can easily make the Meatloaf Grilled Cheese recipe gluten-free by using gluten-free bread for the sandwiches. Additionally, ensure that any other ingredients such as meatloaf or cheese are certified gluten-free if necessary.
  4. Can I add other ingredients to the sandwich? Absolutely! The Meatloaf Grilled Cheese recipe is versatile, and you can customize it by adding additional ingredients such as caramelized onions, sautéed mushrooms, crispy bacon, or sliced tomatoes. Get creative and tailor the sandwiches to your liking.
  5. Can I make these sandwiches ahead of time for a party? While it’s best to serve the Meatloaf Grilled Cheese sandwiches fresh off the grill for optimal taste and texture, you can prepare the individual components (meatloaf slices, cheese, bread) in advance and assemble them just before grilling. This allows for easier preparation while still ensuring a delicious outcome.


In conclusion, our Meatloaf Grilled Cheese recipe is a delightful fusion of two beloved comfort foods that’s sure to become a new favorite in your household. With its savory meatloaf, melted cheese, and crispy grilled bread, this sandwich offers the perfect balance of flavors and textures in every bite. Whether you’re craving a quick and easy meal or looking to impress your family and friends with a gourmet twist on a classic favorite, this recipe delivers on taste, simplicity, and satisfaction. So why wait? Fire up the skillet and treat yourself to the deliciousness of Meatloaf Grilled Cheese tonight!