Saddle up and embark on a culinary journey through the heart of the Wild West with our mouthwatering Cattle Drive Casserole recipe. This Tex-Mex inspired dish is a savory sensation that combines tender ground beef, zesty spices, creamy cheeses, and a hint of green chilies for an unforgettable flavor experience. Perfect for feeding a hungry crowd or enjoying as a comforting family meal, this casserole is sure to become a new favorite in your recipe repertoire.


  • 1 1/2 pounds of ground beef
  • 1 onion, finely minced
  • 1 packet of taco seasoning
  • 1/2 cup of sour cream
  • 1/2 cup of mayonnaise
  • 1 cup of shredded cheddar cheese, divided
  • 1 cup of shredded pepper jack cheese, divided
  • One 4-ounce can of diced green chilies, drained
  • 2 cups of Bisquick mix
  • 1 cup of water


  1. Preheat your oven to 350°F (175°C) and grease a 9×13-inch casserole dish to prepare for your culinary adventure.
  2. In a skillet over medium-high heat, brown the ground beef with the taco seasoning until it’s perfectly cooked through, then add in the minced onion and diced green chilies, sautéing until the onion becomes tender and aromatic.
  3. In a mixing bowl, blend together the sour cream, mayonnaise, half of the shredded cheddar cheese, and half of the shredded pepper jack cheese until they form a creamy, indulgent mixture. Set this delectable concoction aside for later.
  4. In a separate bowl, stir together the Bisquick mix and water until they combine into a soft, doughy consistency.
  5. Now, spread the Bisquick dough evenly across the bottom of your prepared casserole dish, creating a delicious foundation for your culinary masterpiece.
  6. Next, layer on the savory cooked ground beef mixture, ensuring it covers the Bisquick layer with a hearty blanket of flavor.
  7. Once your beef layer is in place, generously spread the creamy sour cream mixture over the top, adding a luscious touch that will elevate every bite.
  8. Sprinkle the remaining shredded cheddar and pepper jack cheeses over the casserole, providing a tantalizing finish that promises a gooey, golden-brown crust.
  9. Slide your casserole creation into the preheated oven and bake for approximately 30 minutes, or until the cheese is bubbling and irresistibly melted.
  10. Once baked to perfection, remove your Cattle Drive Casserole from the oven and let it cool slightly before serving.

Serving Tips:

  1. Serve your Cattle Drive Casserole piping hot straight from the oven for maximum flavor and enjoyment.
  2. Garnish each serving with a dollop of sour cream, a sprinkle of chopped green onions, or a handful of fresh cilantro to add a pop of color and freshness.
  3. Pair the casserole with classic Tex-Mex sides such as Spanish rice, refried beans, or a crisp garden salad to create a well-rounded and satisfying meal.
  4. For a festive touch, set out bowls of salsa, guacamole, and sliced jalapeños as optional toppings, allowing guests to customize their portions according to their taste preferences.

Storage Tips:

  1. Allow any leftover casserole to cool completely before transferring it to an airtight container or wrapping it tightly with aluminum foil.
  2. Refrigerate the leftover casserole within two hours of cooking and consume it within 3-4 days for optimal freshness and flavor.
  3. To reheat individual servings, microwave them on high for 1-2 minutes or until heated through, or place the entire casserole dish back in the oven at 350°F (175°C) for 15-20 minutes.
  4. You can also freeze portions of the cooked casserole for longer storage. Wrap tightly in plastic wrap and aluminum foil, or use freezer-safe containers, and label with the date before freezing. The casserole can be stored in the freezer for up to 2-3 months.
  5. When ready to enjoy frozen leftovers, thaw them overnight in the refrigerator before reheating according to the instructions above.


  1. Can I substitute ground turkey or chicken for the ground beef in the Cattle Drive Casserole recipe? Absolutely! Ground turkey or chicken can be excellent alternatives for those seeking a lighter option or who prefer poultry over beef. Just be sure to adjust the cooking time accordingly, as poultry typically cooks faster than beef.
  2. Can I make the Cattle Drive Casserole ahead of time and bake it later? Yes, you can assemble the casserole ahead of time and refrigerate it, covered, until you’re ready to bake it. This makes it a convenient option for busy weeknights or when preparing for gatherings. Simply remove it from the refrigerator about 30 minutes before baking to allow it to come to room temperature, then bake as directed in the recipe.
  3. Can I use a gluten-free Bisquick mix for this recipe? Absolutely! If you’re following a gluten-free diet, you can use a gluten-free Bisquick mix as a suitable alternative. Just be sure to check the ingredient list to ensure it meets your dietary requirements.
  4. Can I add extra vegetables to the Cattle Drive Casserole? Of course! Feel free to customize the recipe to suit your taste preferences. You can add diced bell peppers, corn kernels, black beans, or any other favorite veggies to the ground beef mixture for added flavor and nutrition. Simply sauté them along with the onion and green chilies until tender before assembling the casserole.
  5. Can I make a vegetarian version of the Cattle Drive Casserole? Absolutely! You can easily adapt this recipe to make a vegetarian version by substituting the ground beef with cooked lentils, crumbled tofu, or a meatless ground beef alternative. Just be sure to season your vegetarian filling well to ensure it’s packed with flavor.


With its harmonious blend of savory flavors and comforting textures, our Cattle Drive Casserole is sure to be a hit at any gathering or family dinner. Whether you’re a seasoned cowboy or a city slicker craving a taste of the frontier, this hearty dish is guaranteed to satisfy your hunger and leave you craving more. So round up your ingredients, fire up the oven, and get ready to rustle up some savory bliss with our Cattle Drive Casserole recipe today!